Two sample MR report
ZNF506_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0351818 | 0.1342129 | 0.8101870 |
| Weighted median | 5 | 0.0299093 | 0.0087003 | 0.0005866 |
| Inverse variance weighted | 5 | 0.0247809 | 0.0062798 | 0.0000794 |
| Simple mode | 5 | 0.0340705 | 0.0128082 | 0.0563870 |
| Weighted mode | 5 | 0.0338747 | 0.0134457 | 0.0654008 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.675137 | 3 | 0.2987476 |
| Inverse variance weighted | 3.682514 | 4 | 0.4506742 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0112988 | 0.1456051 | 0.9430326 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.05e-05 | 0 | TRUE | 0.5059142 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
